Human Factor XII

Purified from fresh frozen human plasma. Human Factor XII is part of the contact activation system. Human Factor XII is a single chain glycoprotein with a molecular weight of about 80,000. Once activated, principally from the action of kallikrein, Factor XII is converted into an active serine protease (Factor α-Xlla) that functions in the in vivo initiation of blood coagulation, fibrinolysis, and kinin formation. Human Factor XII has been purified by ion exchange chromatography. Protein purity is determined by SDS-PAGE and activity is determined via clotting assay.

Buffer composition = 4 mM Sodium Acetate-HCl/0.15 M NaCl/pH 5.3 
Extinction Coefficient (1%) =14.1
Molecular Weight = 80,000 daltons

Sample SDS-PAGE

Antibodies: GAFXII-IG, GAFXII-AP, GAFXII-HRP FXII-EIA, Mab HFXII